Vetenskapliga publikationer - Alligator Bioscience

Sveriges lantbruksuniversitet - Primo - SLU-biblioteket

Soluble CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells. AU - Lindstedt, Malin. AU - Johansson Lindbom, Bengt.

och omsider front 136. aflågger til K. SIGISMUNDUS fin trohets cd 137. APV-527 är designad för att binda till både 5T4 och den co-stimulerande receptorn 4-1BB (CD137) och på så sätt ge en kraftfull och tumörriktad Institutionen för Medicin, Solna TUMOR NECROSIS FACTOR SUPERFAMILY MEMBERS CD137 AND OX40 LIGAND IN VASCULAR INFLAMMATION 4-1BB (CD137) ligandförstärkt anti-tumörimmunrespons mot mus Forestomach-karcinom in vivo. CD137 is a member of the tumor necrosis factor receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).

Therefore, CD137 can act as a surrogate marker for T cell activation. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells.

Stellan Sagvik - Missa Maria Magdalena - nosag records CD137

AU - Lindstedt, Malin. AU - Johansson Lindbom, Bengt. AU - Borrebaeck, Carl.

Farliga egenskaper - Cell Signaling Technology

CD137-transfected L-428 cells (L-428-CD137) were treated with 10 μg/ml of Fabs, followed by anti-Fab-AF647. All Fabs bound efficiently to CD137 + cells ( Supplementary Figure 3 ). No binding was observed to CD137 − L-428-control cells (not shown). 137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. The CD137 receptor (4-1BB, TNF RSF9) is an activation induced molecule expressed by antigen-specific T-cells. The engagement with its ligand, CD137L, is capable of increasing T-cell survival, proliferation, and cytokine production.

Två antikroppar som kan aktivera T-celler genom bindning till CD137 studerades. antitumöreffekt och förstärker effekten av behandling med anti-PD-1 och anti-CD137 i djurmodeller --. Immunicum AB (publ; IMMU. Combination treatment with ilixadencel and the immune enhancer anti-CD137 had a synergistic effect in delaying tumor progression and CD137 är en medlem av tumörnekrosfaktor ( TNF ) -receptorfamiljen.
Bli besiktningsman bygg

No binding was observed to CD137 − L-428-control cells (not shown). 137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. The CD137 receptor (4-1BB, TNF RSF9) is an activation induced molecule expressed by antigen-specific T-cells. The engagement with its ligand, CD137L, is capable of increasing T-cell survival, proliferation, and cytokine production. This allowed to identify the CD137+ T-cells as the real tumor-specific activated T-cell population.

T cell.
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Underlag beslut Tecentriq - TLV

It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily.

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Stellan Sagvik - Missa Maria Magdalena - nosag records CD137

4-1BB is also expressed on Tregs and DCs. CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes. Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses. CD137 is a kind of surface glycoprotein, which was originally discovered in the late 1980s. 6 It has been found that CD137 is expressed in a vari- ety of cells, for example, T cells, B cells, natural killer (NK) cells, dendritic CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells. CD137.